Antagonists on the cytokine network of patients with oligoarticular idiopathic
arthritis cheap beats by dre solo ojia 1Center
for Pediatric and Adolescent Medicine, Pediatric Immunology and Rheumatology
Johannes GutenbergUniversity of Mainz, Mainz, GermanyMethods:Lipopolysaccharid
stimulation was performed in vitro on peripheral mononuclear cells from 10
patients with ojia and website 15 healthy individuals for
24 hours.Etanercept, anakinra and adalimumab were used to inhibit cytokine
effects.In the collected culture supernatants the profile of cytokine production
was studied by multiplex cytokine bead immunoassay. Results:In healthy
individuals selective cytokine inhibition prevented proinflammatory cytokine
production collectively.In ojia cell cultures with adalimumab or anakinra tnf or
il1 concentrations were significantly decreased.In contrast this could not be
shown for etanercept(Tnf we found decreased amounts of proinflammatory cytokines
il1 and ifny.A decrease of il6 could be achieved only with anakinra and
etanercept.Interestingly, after blockade of tnf or il1 we found increases in
concentrations of proinflammatory il8 and antiinflammatory il4.
Conclusions:Blockade of cytokine effects of tnf or il1 may cause the decline of
further proinflammatory cytokines in ojia patients.This selective
antiinflammatory effect is likely supported by an increase of il4.The
simultaneous presence of proinflammatory il8 seems to account for the
maintenance of autoinflammation.This could be an attempt to explain the
pathogenesis of therapyresistant disease progression in anticytokine
therapy.Hence, the use of humanized antibodies against il8 may play a role beats by dre
solo hd in future treatment of jia.
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